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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: TBB4B_HUMAN




USC-OGP 2-DE database:  TBB4B_HUMAN


TBB4B_HUMAN


General information about the entry
View entry in simple text format
Entry nameTBB4B_HUMAN
Primary accession numberP68371
Secondary accession number(s) P05217
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Tubulin beta-4B chain; AltName: Full=Tubulin beta-2 chain; AltName: Full=Tubulin beta-2C chain;.
Gene nameName=TUBB4B
Synonyms=TUBB2C
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-5 {PLATELET 4-5}
Homo sapiens (Human)
PLATELET_4-5
  map experimental info
 
PLATELET_4-5

MAP LOCATIONS:
pI=4.86; Mw=51629
pI=4.95; Mw=51402
pI=4.81; Mw=27222



PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info
 
PLATELET_4-7

MAP LOCATIONS:
pI=5.00; Mw=49250



PLATELET_5-6 {PLATELET 5-6}
Homo sapiens (Human)
PLATELET_5-6
  map experimental info
 
PLATELET_5-6

MAP LOCATIONS:
pI=5.02; Mw=50928



UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10}
Homo sapiens (Human)
UVEAL_MELANOMA_3-10
  map experimental info
 
UVEAL_MELANOMA_3-10

MAP LOCATIONS:
pI=5.05; Mw=49904
pI=5.74; Mw=37929

Cross-references
UniProtKB/Swiss-ProtP68371; TBB4B_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameTBB4B_HUMAN
Primary accession numberP68371
Secondary accession number(s) A2BFA2 P05217
Sequence was last modified on August 13, 1987 (version 1)
Annotations were last modified on March 15, 2017 (version 138)
Name and origin of the protein
DescriptionRecName: Full=Tubulin beta-4B chain; AltName: Full=Tubulin beta-2 chain; AltName: Full=Tubulin beta-2C chain;
Gene nameName=TUBB4B
Synonyms=TUBB2C
Encoded onName=TUBB4B; Synonyms=TUBB2C
KeywordsAcetylation; Complete proteome; Cytoplasm; Cytoskeleton; GTP-binding; Isopeptide bond; Microtubule; Nucleotide-binding; Phosphoprotein; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX02344; CAA26203.1; -; Genomic_DNA
EMBLBX255925; CAM24148.1; -; Genomic_DNA
EMBLBC001911; AAH01911.1; -; mRNA
EMBLBC002783; AAH02783.1; -; mRNA
EMBLBC002885; AAH02885.1; -; mRNA
EMBLBC004188; AAH04188.1; -; mRNA
EMBLBC007889; AAH07889.1; -; mRNA
EMBLBC012835; AAH12835.1; -; mRNA
EMBLBC019359; AAH19359.1; -; mRNA
EMBLBC019829; AAH19829.1; -; mRNA
EMBLBC039175; AAH39175.1; -; mRNA
EMBLBC071889; AAH71889.1; -; mRNA
CCDSCCDS7039.1; -; .
PIRI38370; I38370; .
RefSeqNP_006079.1; NM_006088.5; .
UniGeneHs.433615; -; .
ProteinModelPortalP68371; -; .
SMRP68371; -; .
BioGrid115656; 143; .
IntActP68371; 61; .
MINTMINT-1390314; -; .
STRING9606.ENSP00000341289; -; .
ChEMBLCHEMBL1848; -; .
DrugBankDB00518; Albendazole; .
DrugBankDB05147; CYT997; .
DrugBankDB03010; Epothilone B; .
DrugBankDB01873; Epothilone D; .
DrugBankDB00643; Mebendazole; .
DrugBankDB04910; Oxibendazole; .
iPTMnetP68371; -; .
PhosphoSitePlusP68371; -; .
SwissPalmP68371; -; .
BioMutaTUBB4B; -; .
DMDM55977480; -; .
OGPP05217; -; .
REPRODUCTION-2DPAGEIPI00007752; -; .
SWISS-2DPAGEP68371; -; .
EPDP68371; -; .
MaxQBP68371; -; .
PaxDbP68371; -; .
PeptideAtlasP68371; -; .
PRIDEP68371; -; .
TopDownProteomicsP68371; -; .
DNASU10383; -; .
EnsemblENST00000340384; ENSP00000341289; ENSG00000188229; .
GeneID10383; -; .
KEGGhsa:10383; -; .
UCSCuc004cmh.2; human; .
CTD10383; -; .
DisGeNET10383; -; .
GeneCardsTUBB4B; -; .
HGNCHGNC:20771; TUBB4B; .
HPACAB010880; -; .
HPAHPA043640; -; .
HPAHPA046280; -; .
MIM602660; gene; .
neXtProtNX_P68371; -; .
OpenTargetsENSG00000188229; -; .
PharmGKBPA142670672; -; .
eggNOGKOG1375; Eukaryota; .
eggNOGCOG5023; LUCA; .
GeneTreeENSGT00760000119061; -; .
HOGENOMHOG000165710; -; .
HOVERGENHBG000089; -; .
InParanoidP68371; -; .
KOK07375; -; .
OMAFWEVIND; -; .
OrthoDBEOG091G06U2; -; .
PhylomeDBP68371; -; .
TreeFamTF300298; -; .
ReactomeR-HSA-1445148; Translocation of GLUT4 to the plasma membrane; .
ReactomeR-HSA-190840; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; .
ReactomeR-HSA-190861; Gap junction assembly; .
ReactomeR-HSA-2132295; MHC class II antigen presentation; .
ReactomeR-HSA-2467813; Separation of Sister Chromatids; .
ReactomeR-HSA-2500257; Resolution of Sister Chromatid Cohesion; .
ReactomeR-HSA-2565942; Regulation of PLK1 Activity at G2/M Transition; .
ReactomeR-HSA-380259; Loss of Nlp from mitotic centrosomes; .
ReactomeR-HSA-380270; Recruitment of mitotic centrosome proteins and complexes; .
ReactomeR-HSA-380284; Loss of proteins required for interphase microtubule organization from the centrosome; .
ReactomeR-HSA-380320; Recruitment of NuMA to mitotic centrosomes; .
ReactomeR-HSA-389957; Prefoldin mediated transfer of substrate to CCT/TriC; .
ReactomeR-HSA-389960; Formation of tubulin folding intermediates by CCT/TriC; .
ReactomeR-HSA-389977; Post-chaperonin tubulin folding pathway; .
ReactomeR-HSA-437239; Recycling pathway of L1; .
ReactomeR-HSA-5610787; Hedgehog 'off' state; .
ReactomeR-HSA-5617833; Cilium Assembly; .
ReactomeR-HSA-5620912; Anchoring of the basal body to the plasma membrane; .
ReactomeR-HSA-5620924; Intraflagellar transport; .
ReactomeR-HSA-5626467; RHO GTPases activate IQGAPs; .
ReactomeR-HSA-5663220; RHO GTPases Activate Formins; .
ReactomeR-HSA-6798695; Neutrophil degranulation; .
ReactomeR-HSA-6807878; COPI-mediated anterograde transport; .
ReactomeR-HSA-6811434; COPI-dependent Golgi-to-ER retrograde traffic; .
ReactomeR-HSA-6811436; COPI-independent Golgi-to-ER retrograde traffic; .
ReactomeR-HSA-68877; Mitotic Prometaphase; .
ReactomeR-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; .
ReactomeR-HSA-8854518; AURKA Activation by TPX2; .
ReactomeR-HSA-983189; Kinesins; .
SIGNORP68371; -; .
ChiTaRSTUBB4B; human; .
GeneWikiTUBB2C; -; .
GenomeRNAi10383; -; .
PROPR:P68371; -; .
ProteomesUP000005640; Chromosome 9; .
BgeeENSG00000188229; -; .
CleanExHS_TUBB2C; -; .
GenevisibleP68371; HS; .
GOGO:0035578; C:azurophil granule lumen; TAS:Reactome; .
GOGO:0005856; C:cytoskeleton; TAS:ProtInc; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0031012; C:extracellular matrix; IDA:BHF-UCL; .
GOGO:0005576; C:extracellular region; TAS:Reactome; .
GOGO:1903561; C:extracellular vesicle; IDA:UniProtKB; .
GOGO:0005874; C:microtubule; IDA:UniProtKB; .
GOGO:0015630; C:microtubule cytoskeleton; IDA:HPA; .
GOGO:0043209; C:myelin sheath; IEA:Ensembl; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:0003725; F:double-stranded RNA binding; IDA:MGI; .
GOGO:0005525; F:GTP binding; IEA:UniProtKB-KW; .
GOGO:0003924; F:GTPase activity; IEA:InterPro; .
GOGO:0042288; F:MHC class I protein binding; TAS:UniProtKB; .
GOGO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro; .
GOGO:0051082; F:unfolded protein binding; NAS:UniProtKB; .
GOGO:0097711; P:ciliary basal body docking; TAS:Reactome; .
GOGO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome; .
GOGO:0007017; P:microtubule-based process; IEA:InterPro; .
GOGO:0006928; P:movement of cell or subcellular component; TAS:ProtInc; .
GOGO:0042267; P:natural killer cell mediated cytotoxicity; NAS:UniProtKB; .
GOGO:0043312; P:neutrophil degranulation; TAS:Reactome; .
Gene3D1.10.287.600; -; 1; .
Gene3D3.30.1330.20; -; 1; .
Gene3D3.40.50.1440; -; 1; .
InterProIPR013838; Beta-tubulin_BS; .
InterProIPR002453; Beta_tubulin; .
InterProIPR008280; Tub_FtsZ_C; .
InterProIPR000217; Tubulin; .
InterProIPR018316; Tubulin/FtsZ_2-layer-sand-dom; .
InterProIPR023123; Tubulin_C; .
InterProIPR017975; Tubulin_CS; .
InterProIPR003008; Tubulin_FtsZ_GTPase; .
PANTHERPTHR11588; PTHR11588; 1; .
PfamPF00091; Tubulin; 1; .
PfamPF03953; Tubulin_C; 1; .
PRINTSPR01163; BETATUBULIN; .
PRINTSPR01161; TUBULIN; .
SMARTSM00864; Tubulin; 1; .
SMARTSM00865; Tubulin_C; 1; .
SUPFAMSSF52490; SSF52490; 1; .
SUPFAMSSF55307; SSF55307; 1; .
PROSITEPS00227; TUBULIN; 1; .
PROSITEPS00228; TUBULIN_B_AUTOREG; 1; .



USC-OGP 2-DE database image


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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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